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Case Report



J Korean Med Sci. 2003 Aug;18(4):592-594. English.
Published online Apr 22, 2009.혻혻http://dx.doi.org/10.3346/jkms.2003.18.4.592
Copyright 짤 2003 The Korean Academy of Medical Sciences
Hemophagocytic Syndrome Associated with Kikuchi's Disease
Young Mi Kim, Yoon Jin Lee, Sang Ook Nam, Su Eun Park, Ji Yoen Kim and Eun Yup Lee
Department of Pediatrics, College of Medicine, Pusan National University, Busan, Korea.
Department of Surgical Pathology, College of Medicine, Pusan National University, Busan, Korea.
Department of Clinical Pathology, College of Medicine, Pusan National University, Busan, Korea.


Abstract

A 13-yr-old female was admitted to our hospital with fever, seizure, and cervical lym-phadenopathy. Laboratory data showed pancytopenia, elevation of serum transaminase, lactate dehydrogenase, triglyceride, and ferritin levels. Lymph node biopsy revealed features of Kikuchi's disease and there were signs of histiocytosis and hemophagocytic phenomenon in bone marrow. She recovered after treatment with intravenous immunoglobulin and corticosteroids therapy. Hemophagocytic syndrome can be associated with Kikuchi's disease especially in childhood and seems to have a less aggressive clinical course and better prognosis.

Keywords: Histiocytic Necrotizing Lymphadenitis; Kikuchi's Disease; Histiocytosis