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Revised on 14 May 2009 (10th Revision)
 

The Journal of Korean Medical Science (JKMS) is an international, peer-reviewed bimonthly journal of medicine published in English. The Journal’s publisher is the Korean Academy of Medical Sciences (KAMS). JKMS aims to publish evidence-based, scientific research articles from various disciplines of the medical sciences. The Journal welcomes articles of general interest to medical researchers especially when they contain original information. Articles on the clinical evaluation of drugs and other therapies, epidemiologic studies of the general population, studies on pathogenic organisms and toxic materials, and the toxicities and adverse effects of therapeutics are welcome. When an article is written in a language other than English and has not been propagated in any international information services (abstract journals), secondary publication of the article is negotiable.


I. MANUSCRIPT SUBMISSION

Authors should submit manuscripts via the electronic manuscript management system for JKMS, http://esubmit.jkms.org. Please log in first as a member of the system and follow the directions. Manuscripts should be submitted by the corresponding author, who should indicate the address and phone number for correspondence in the title page of the manuscript. If available, a fax number and e-mail address would be helpful. The revised manuscript should be submitted through the same web system under the same identification numbers.

Queries concerning manuscript submission should be directed to:

Editor-in-Chief, Professor Sung-Tae Hong through
Tel: 82-2-740-8373
Fax: 82-2-765-6142
E-Mail: jkms@kams.or.kr
Mail address:
Department of Parasitology and Tropical Medicine,
Seoul National University College of Medicine,
#103 Daehangno Jongno-gu,
Seoul 110-799, Korea


II. CATEGORIES OF PUBLICATIONS

JKMS publishes editorials, invited review articles, original articles, case reports, and correspondences.

Editorials are invited perspectives on an area of medical science, dealing with very active fields of research, current medical interests, fresh insights and debates.

Invited review articles provide a concise review of a subject of importance to medical researchers written by an invited expert in medical science.

Original articles are papers reporting the results of basic and clinical investigations that are sufficiently well documented to be acceptable to critical readers.

Case reports deal with clinical cases of medical interest or innovation.

Brief communications are short original research articles on issues important to medical researchers.

Correspondence includes a reader’s comment on an article published in JKMS and a reply from the authors.



III. EDITORIAL AND PEER REVIEW PROCESS

JKMS reviews all manuscripts received. A manuscript is first reviewed for its format and then sent to the 3 most relevant investigators available for review of the contents. The editor selects peer referees by recommendation of the Editorial Board members or from the Board’s specialist database. In addition, if deemed necessary, a review of statistics may be requested. Authors’ names and affiliations are removed during peer review. Acceptance of the manuscript is decided based on the critiques and recommended decision of the referees. A referee may recommend "acceptance without revision," "acceptance after minor revisions," "review again after revisions," or "rejection." If there is a marked discrepancy in the decisions between two referees or between the opinions of the author and referee(s), the Editor may send the manuscript to another referee for additional comments and a recommended decision. Three repeated decisions of "review again after revision" are regarded as a "rejection." The reviewed manuscripts are returned back to the corresponding author with comments and recommended revisions. Names and decisions of the referees are masked. A final decision on acceptance for publication or rejection for publication is forwarded to the corresponding author from the Editorial Office. The usual reasons for rejection are topics that are too specific and target an audience that is too limited, insufficient originality, serious scientific flaws, poor quality of illustrations, or absence of a message that might be important to readers. Rarity of a disease condition is itself not an acceptable justification for a case report. The peer review process takes usually four to eight weeks after the manuscript submission.

Revisions are usually requested to take account of criticisms and comments made by referees. The revised manuscript should be resubmitted via the web system. Failure to resubmit the revised manuscript within 2 months without any notice from the corresponding author is regarded as a withdrawal. The corresponding author must indicate clearly what alterations have been made in response to the referee’s comments point by point. Acceptable reasons should be given for noncompliance with any recommendation of the referees.


IV. EDITORIAL POLICY

The Editor assumes that all authors listed in a manuscript have agreed with the following policy of JKMS on submission of manuscripts. Except for the negotiated secondary publication, manuscripts submitted to the Journal must be previously unpublished and not be under consideration for publication elsewhere. Under any circumstances, the identities of the referees will not be revealed. If a new author should be added or an author should be deleted after the submission, it is the responsibility of the corresponding author to ensure that the authors concerned are aware of and agree to the change in authorship. JKMS has no responsibility for such changes. Minimum page charges and additional fees for reprints will be due for every manuscript. Costs for printing color illustrations are charged to the authors. All published manuscripts become the permanent property of the KAMS and may not be published elsewhere without written permission.


V. ETHICAL CONSIDERATIONS

Research Ethics

All of the manuscripts should be prepared in strict observation of research and publication ethics guidelines recommended by the Council of Science Editors, International Committee of Medical Journal Editors, World Association of Medical Editors, and the Korean Association of Medical Journal Editors. Any study including human subjects or human data must be reviewed and approved by a responsible institutional review board (IRB). Please refer to the principles embodied in the Declaration of Helsinki (http://www.wma.net/e/policy/b3.htm) for all investigations involving human materials. Animal experiments also should be reviewed by an appropriate committee (IACUC) for the care and use of animals. Also studies with pathogens requiring a high degree of biosafety should pass review of a relevant committee (IBC). The editor of JKMS may request submission of copies of informed consents from human subjects in clinical studies or IRB approval documents.

Conflict of Interest

The corresponding author of an article is asked to inform the Editor of the authors’ potential conflicts of interest possibly influencing their interpretation of data. A potential conflict of interest should be disclosed in the cover letter even when the authors are confident that their judgments have not been influenced in preparing the manuscript. Such conflicts may be financial support or private connections to pharmaceutical companies, political pressure from interest groups, or academic problems. The Editor will decide whether the information on the conflict should be included in the published paper. Before publishing such information, the Editor will consult with the corresponding author. In particular, all sources of funding for a study should be explicitly stated. The JKMS asks referees to let its Editor know of any conflict of interest before reviewing a particular manuscript.

Authorship

Authorship credit should be based on 1) substantial contributions to conception and design, acquisition of data, or analysis and interpretation of data; 2) drafting the article or revising it critically for important intellectual content; and 3) final approval of the version to be published. Authors should meet conditions 1, 2, and 3.

When a large, multicenter group has conducted the work, the group should identify the individuals who accept direct responsibility for the manuscript. When submitting a manuscript authored by a group, the corresponding author should clearly indicate the preferred citation and identify all individual authors as well as the group name. Journals generally list other members of the group in the Acknowledgments. Acquisition of funding, collection of data, or general supervision of the research group alone does not constitute authorship.

Redundant Publication and Plagiarism

Redundant publication is defined as “reporting (publishing or attempting to publish) substantially the same work more than once, without attribution of the original source(s)”. Characteristics of reports that are substantially similar include the following: (a) “at least one of the authors must be common to all reports (if there are no common authors, it is more likely plagiarism than redundant publication),” (b) “the subject or study populations are often the same or similar,” (c) “the methodology is typically identical or nearly so,” and (d) “the results and their interpretation generally vary little, if at all.”

When submitting a manuscript, authors should include a letter informing the editor of any potential overlap with other already published material or material being evaluated for publication and should also state how the manuscript submitted to JKMS differs substantially from this other material. If all or part of your patient population was previously reported, this should be mentioned in the Materials and Methods, with citation of the appropriate reference(s)



VI. MANUSCRIPT PREPARATION AND FORMAT

1. Original Articles

The manuscript should be prepared according to "Uniform Requirements for Manuscripts submitted to Biomedical Journals" (2008) ( http://www.icmje.org).

In addition to the Uniform Requirements, a number of reporting guidelines have been developed by groups of experts to facilitate reporting of research studies or clinical trials (http://www.equator-network.org/resource-centre/library-of-health-research-reporting/library/). The JKMS requires compliance with some or all of the following reporting guidelines:

CONSORT Statement (reporting of randomized controlled trials)
STARD (reporting of diagnostic accuracy studies)
STROBE (reporting of observational studies in epidemiology)
QUOROM, recently renamed PRISMA (reporting of systematic reviews
MOOSE (reporting of meta-analyses of observational studies)


All materials must be written in proper and clear English. The manuscript including tables and their footnotes, and figure legends, must be typed in one double space. Materials should be prepared with a standard 12-point font. The manuscript should be in the following sequence: title page, abstract and key words, introduction, materials and methods, results, discussion, acknowledgments, references, tables, and figure legends. All pages should be numbered consecutively starting from the title page. All numbers should be written in Arabic numerals throughout the manuscripts except for the first word of a sentence.

Our preferred file type for new manuscript submissions is Adobe Acrobat portable document format (.PDF) with all figures inserted in the same document. We will also accept Microsoft Office Word (DOC), WordPerfect (.WPD), and text (.TXT) documents or (.RTF) file format. Acceptable formats for pictures, photos, and figures are PDF, DOC, PPT, JPG, GIF, TIF, and BMP.

You may either insert figures in the text file or upload your figures separately. It is permissible to send low-resolution images for peer review, although we may ask for high-resolution files later.

Title Page:
The title page should contain the title of an article, full names of authors, and institutional affiliation(s). If several authors and institutions are listed, it should be clearly indicated with which department and institution each author is affiliated by using superscript numbers in sequence. In a separate paragraph, an address for correspondence, including the name of corresponding author, academic degree, address (institutional affiliation, city, zip code and country), telephone and fax numbers, and email address (if present), should be given. Information concerning sources of financial support should be placed as a footnote. The running title of less than 10 words should not be a declarative or interrogative sentence. One original article should not exceed these maximums: word count from introduction to conclusion, 5500 words; number of references, 30; number of figure parts, 10; number of tables, 5. Any article longer than these limits should be discussed with the editor.

Abstract and Key Words:
The abstract should be concise, less than 200 words, and describe concisely, in a paragraph the purpose, methods, important results, and derived conclusions of the study in an unstructured format. Abbreviations, if needed, should be kept to an absolute minimum with proper identifications. Up to 10 key words should be listed at the end of the abstract to be used as index terms. For the selection of key words, refer to Medical Subject Headings (MeSH) in Index Medicus, or at the internet site, http://www.nlm.nih.gov/mesh/MBrowser.html.

Introduction:
A brief background, references to the most pertinent papers general enough to inform readers, and the relevant findings of others should be included. The specific question that the authors' particular investigation studied should also be stated.

Materials and Methods:
The explanation of the experimental methods should be concise and sufficient for repetition by other qualified investigators. Procedures that have been published previously should not be described in detail. However, new or significant modifications of previously published procedures need full descriptions. Clinical studies or experiments using laboratory animals or pathogens should mention approval of the studies by relevant committees in this section. The sources of special chemicals or preparations should be given along with their location (name of company, city and state, and country). Method of statistical analyses and the criteria for determining significance levels should be described.

Results:
This section should be presented logically using text, tables and illustrations. Excessive repetition of table or figure contents should be avoided.

Discussion:
The data should be interpreted concisely without repeating materials already presented in the results section. Speculation is permitted, but it must be directly supported by the presented data of the authors and be well founded.

Acknowledgments:
All persons who have made substantial contribution, but who are not eligible as authors should be named in the acknowledgments.


References:
Citation of references in the text should be made by giving consecutive numbers in parenthesis (Vancouver style). They should be listed in the order of citation in the text with consecutive numbers in this separate section. The style for citing papers in periodicals is: name and initials of all authors, full title of article, journal name abbreviated in accordance with Index Medicus, year, volume, and first and last page numbers. The style for a chapter of a book is: author and title of the chapter, editor of the book, title of the book, edition, volume, place, publisher, year, and first and last page numbers. All other references should be listed as shown in the "Uniform Requirements for Manuscripts submitted to Biomedical Journals" (2008). Authors are responsible for the accuracy and completeness of their references and correct text citations. Papers in press may be listed among the references with the journal name and tentative year of publication. Unpublished data or personal communications can be listed only with the author's written permission. The maximum number of cited references should be 30.

Examples of Reference Style:

1. Park MS, Chung SY, Chang Y, Kim K. Physical activity and physical fitness as predictors of all-cause mortality in Korean men. J Korean Med Sci 2009; 24: 13-9.

2. Floch MH. Probiotics, probiotics and dietary fiber. In: Buchman A, editor, Clinical nutrition: a guide for gastroenterologists. Thorofare, NJ: Slack Incorporated, 2005, p18-24.


3. WHO. WHO statistical information system. Available at http://www.who.int/whosis/en/menu.cfm [accessed on 1 April 2009].

Tables and Figures:
Tables and figures should be submitted separately from the text, and figure legends should be typed on separate sheets. Tables should be simple and should not duplicate information in figures. Title all tables and number them with Arabic numerals in the order of their citation. Type each table on a separate sheet. Explain all abbreviations. Each column should have an appropriate heading, and if numerical measurements are given, the unit should be added to column headings. The significance of results should be indicated by appropriate statistical analysis. Table footnotes should be indicated with superscript symbols in sequence: *, †, ‡, §, ∥, ¶, **, ††, ‡‡. All units of measurements and concentrations should be designated. Exponential terminology is discouraged. Flow diagram and complex biochemical structures should be prepared professionally. Graphics should be used only when a relevant point needs illustration. X-ray films or Polaroid photographs are not acceptable. Except for especially complicated drawings, which show a large amount of data, all figures are published in one-page or one column width. When the figures are reduced to the size of a single-column or of a single-page width, the smallest parts of the figure must be legible.

Points of observation should be noted with different symbols rather than with different types of lines and their significance can be directly shown in the body of the figure or in the legend. If a figure contains a left- or right-hand ordinate, explanation of the left ordinate should read in the upward direction and that of the latter should read downward.

All photographs should be of the highest quality. The preferred size of photograph is 8 ´ 8 cm, but one-page width (16.5 cm in width ´ 8 cm in length) is also acceptable. The entire expense of reproducing color photographs will be charged to the author. The author is responsible for submitting figure files that are of sufficient quality to permit accurate reproduction, and for approving the final color galley proof. All photographs should be correctly exposed, sharply focused, and prepared in files of 500 dpi or more. The JKMS assumes no responsibility for the quality of the photographs as they appear in the Journal. Current estimates for color reproduction can be obtained from the Editorial Office. The figure numbers, in Arabic numerals, should appear in figure legends. Multiple figures under one figure number should be marked on the photographs using capital alphabet letters, at the lower right corner. Symbols, arrows, or letters used in photographs should contrast well with background. The legend for each light microscopic photographs should include names of stain and magnification. Electron microscopic photographs should have an internal scale marker. All kinds of figures may be reduced, enlarged or trimmed for publication by the Editor.

All the legends for figures should be typewritten in double space. Do not use separate sheets for each legend. Figure legends should describe briefly the data shown, explain any abbreviations or reference points in the photographs, and identify all units, mathematical expressions, abscissas, ordinates, and symbols. Maximum length, 40 words.



Abbreviations. Except for units of measurement, abbreviations are strongly discouraged. Do not use abbreviations in the title or abstract and limit their use in the text. Expand all abbreviations at first mention in the text.

Units of Measurement. Laboratory values are expressed using conventional units of measure, with relevant Système International (SI) conversion factors expressed secondarily (in parentheses) only at first mention. Figures and tables should use conventional units, with conversion factors given in legends or footnotes. The metric system is preferred for the expression of length, area, mass, and volume.

Names of Drugs, Devices, and Other Products. Generic names should be used. When proprietary brands are used in research, include the brand name and the name of the manufacturer in parentheses after the first mention of the generic name in the Methods section.

Gene Names, Symbols, and Accession Numbers. Authors describing genes or related structures in a manuscript should include the names and official symbols provided by the US National Center for Biotechnology Information (NCBI) or the HUGO Gene Nomenclature Committee.

2. Invited Review Articles

Review articles are generally prepared in the same format as original articles, but the details of manuscript format may be flexible according to the contents. Review articles should not exceed the following maximums: one paragraph abstract, 200 words; word count from introduction to conclusion, 6500 words; number of references, 100; number of figure parts, 24; number of tables, 4. Review articles are accepted after editorial evaluation.

3. Case Reports

The manuscript should be in the following sequence: title page, abstract and key words, introduction, case report, discussion, acknowledgments, references, figures and figure legends. Maximums: one-paragraph unstructured abstract, 150 words; word count from Introduction through Discussion, 1500 words; number of references, 20; number of figure parts, 6; no tables.

4. Brief Communications

A brief communication manuscript should be prepared in the following sequence: title page, abstract and key words, text without section titles, acknowledgments, references, and figures or tables. Maximums: one-paragraph unstructured abstract, 150 words; word counts of the text, 1500 words; number of references, 20; number of figure parts, 2; table, 1.

5. Editorials and Correspondences

An abstract is not required, and a brief text should be prepared with references. Maximum word count of the text is 1000.

VII. INSTRUCTIONS FOR SUBMISSION OF REVISED MANUSCRIPTS

When you prepare a revised version of your manuscript, you should carefully follow the instructions given in the editor’s letter. Please submit both a clean copy of your manuscript and an annotated copy describing the changes you have made. Failure to do so will cause a delay in the review of your revision. If references, tables, or figures are moved, added, or deleted during the revision process, renumber them to reflect such changes so that all tables, references and figures are cited in numeric order.
The annotated copy should have changes highlighted (either by using the Track Changes function in MS Word or by highlighting or underlining the text) with notes in the text referring to the editor or reviewer query.

VIII. FIGURES AND TABLES FOR ACCEPTED MANUSCRIPTS

Graphs and illustrations: Graphs, illustrations, and drawings rendered in professional graphics programs should be submitted in Photoshop (.PSD), TIFF, or encapsulated Postscript (.EPS) format at 1200 dpi. Layers should be retained (ie, do not "flatten" the image). If the graph or illustration was created in MS Excel or Word, we recommend that you submit the original file in the native format (.XLS for Excel, .DOC for MS Word). Files created by vector programs are best for accurately plotting and maintaining data points. Graphs, charts, and diagrams may be imported or copy/pasted into applications such as MS Word or PowerPoint for labeling and formatting, but must be accompanied by vector files created by the statistical software application. o Preferred file formats (vector files): AI, EMF, EPS, PDF, WMF, XLS.

Electronic photographs- photomicrographs, electron micrographs, Western blots, radiographic images, ECG and EEG tracings, and so on-and scanned images must have a resolution of at least 300 dpi. If fonts are used in the artwork, they must be converted to paths or outlines or they must be embedded in the files. Color images must be created/scanned and saved and submitted as CMYK files. Send the electronic original with appropriate labeling and arrows. The following formats are preferred for submission of digital files of photographic images: EPS, TIFF, Adobe Photoshop, JPEG (use only the maximum quality compression setting).

Color is acceptable for charts and graphs. Do not use patterns or textures; use of three-dimensional graphs is discouraged unless all three axes are needed to depict data.

Symbols (e.g., circles, triangles, squares), letters (e.g., words, abbreviations), and numbers should be large enough to be legible on reduction to the journal's column widths. All symbols must be defined in the figure caption. If the symbols are too complex to appear in the caption, they should appear on the illustration itself, within the area of the graph or diagram, not to the side.


IX. AUTHOR'S MANUSCRIPT CHECKLIST

1. Double-spaced typing with 12-point font
2. Sequence of title page, abstract and keywords, introduction, materials and methods, results, discussion, references, and tables and figure legends. All pages should be numbered consecutively starting from the title page.
3. Title page with article title, authors' full name(s) and affiliation, address for correspondence (including telephone and fax numbers and e-mail address), running title (less than 10 words), and footnotes or acknowledgments, if any.
4. Abstract in unstructured format of 200 words maximum for original or review articles, and key words as in MeSH.
5. On the title page, include a word count for text only, exclusive of title, abstract, references, tables, and figure legends.
6. All tables and figure numbers should be found in the text.
7. References listed in a proper format. Check that all references listed in the references section are cited in the text and vice versa.
8. A covering letter stating the material has not been published previously, and will not be submitted for publication elsewhere, and stating conflicts of interest of all listed authors, if any.
9. Include a title for each table and figure (a brief phrase no longer than 10 to 15 words) and explanatory legend as needed.
10. Have each author read, complete, and sign the Authorship Form which includes Copyright Transfer/Publishing Agreement. After submission, add the manuscript number to the top of each authorship form and send it by mail or fax to the editorial office.


X. GALLEY PROOF

JKMS provides the corresponding author with galley proofs for their correction. Corresponding authors will receive electronic page proofs to check the copyedited and typeset article before publication. Portable document format (PDF) files of the typeset pages and support documents (e.g., reprint order form) will be sent to the corresponding author by e-mail. Complete instructions will be provided with the e-mail for downloading and printing the files and for faxing the corrected page proofs to the publisher. Those authors without an e-mail address will receive traditional page proofs.

Corrections should be kept to minimum. The Editor retains the prerogative to question minor stylistic alterations and major alterations that might affect the scientific content of the paper. Authors may be charged for alterations to the proofs beyond those required to correct errors or to answer queries. Any fault found after the publication is the responsibility of the authors. We urge our contributors to proofread their accepted manuscripts very carefully. The corresponding author may be contacted by the Editorial Office, depending on the nature of the correction in the proof. If the proof is not returned or faxed to the Editorial Office within 48 hours, it may be necessary to reschedule the paper for a subsequent issue.


XI. REPRINTS

Authors will receive a reprint order form and a price list with the page proofs. Reprint requests should be faxed to the publisher with the corrected proofs, if possible. Reprints are normally delivered 4 weeks after publication of the issue in which the item appears. Contact the publishing company, Academya, 316 Yangjae-Dong, Seocho-Gu, Seoul, 137-130 Korea (academya@korea.com, phone 822-576-0922, fax 822-577-8091), with any questions.


XII. COPYRIGHT

All authors must sign a copy of the Journal’s "Authorship Responsibility and Copyright Transfer" form and submit it at the time of manuscript submission or fax a copy to +82-2-765-6142.